Elucidation of the receptor-bound conformation of the enkephalins

✍ Scribed by Gorin, Fredric A. ;Balasubramanian, T. M. ;Barry, C. David ;Marshall, Garland R.

• Book ID: 102926547
• Publisher: Wiley (John Wiley & Sons)
• Year: 1978
• Tongue: English
• Weight: 809 KB
• Volume: 9
• Category: Article
• ISSN: 0091-7419
• DOI: 10.1002/jss.400090104

✦ Synopsis

The biologically relevant conformers of enkephalin predicted by solid state, solution state, and theoretical energy studies have been compared with the published structure-activity data on these compounds. No conformational technique proposes a model consistent with all the pharmacological data; the shortcomings of each approach are evaluated. An alternative approach, which correlates the structure-activity data of opiate compounds with that of the enkephalins, is described and shown to produce a model consistent with the available structure-activity data.