Elucidation of the absolute configurations of amino acids and amines by the modified mosher's method
β Scribed by Takenori Kusumi; Toshiro Fukushima; Ikuko Ohtani; Hiroshi Kakisawa
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 226 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The high field NMR application of the Moshr method has been succes&Uy applied to determine the absolute c.o&uation of a tstrrcyclic dihydroxydrimane derivative. l%e result
## Abstract Enantiopure Ξ±βamino acids were converted to 4βsubstituted 2βarylβ and 2βalkylβ5(4__H__)βoxazolones under partial racemization. These nonracemic mixtures were dissolved in CDCl~3~, an equimolar amount of the chiral dirhodium complex $Rh^{\rm (II)}\_{2}$[(__R__)β (+)β MTPA]~4~ (MTPAβH = M
## Abstract A general procedure to determine the absolute configuration of cyclic secondary amines with Mosher's NMR method is demonstrated, with assignment of absolute configuration of isoanabasine as an example. Each Mosher amide can adopt two stable conformations (named rotamers) caused by hinde