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Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2

✍ Scribed by Aimová, Dagmar; Poljaková, Jitka; Kotrbová, Věra; Moserová, Michaela; Frei, Eva; Arlt, Volker; Stiborová, Marie

Book ID: 120015854
Publisher: Versita
Year: 2008
Tongue: English
Weight: 681 KB
Volume: 1
Category: Article
ISSN: 1337-6853
DOI: 10.2478/v10102-010-0033-z

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## Abstract We hypothesized that chlorophyllin (CHLN) would reduce benzo[__a__]pyrene‐DNA (BP‐DNA) adduct levels. Using normal human mammary epithelial cells (NHMECs) exposed to 4 μM BP for 24 hr in the presence or absence of 5 μM CHLN, we measured BP‐DNA adducts by chemiluminescence immunoassay (C