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Elevated substance p and accelerated cartilage degradation in rabbit knees injected with interleukin-1 and tumor necrosis factor

✍ Scribed by Elizabeth M. O'Byrne; Vincent Blancuzzi; Douglas E. Wilson; Mary Wong; Arco Y. Jeng


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
501 KB
Volume
33
Category
Article
ISSN
0004-3591

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✍ Ding, Minzhen ;Hart, Ronald P. ;Miller Jonakait, G. 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 864 KB

## Abstract The present study establishes that tumor necrosis factor‐α (TNF‐α) induction of sympathetic substance P (SP) requires sequential induction of both interleukin (IL‐1) and leukemia inhibitory factor (LIF). TNF‐α dose‐dependently induces SP, an induction that is secondory to an increase in