Plasma concentrations of endothelin, a vasoconstrictor peptide released from vascular endothelial cells, have been measured by radioimmunoassay in 100 patients with diabetes mellitus and 19 healthy subjects. The plasma immunoreactive-endothelin concentrations were found to be greatly raised in the p
β¦ LIBER β¦
Elevated plasma endothelin in diabetes mellitus
β Scribed by K. Takahashi; M.A. Ghatei; H.-C. Lam; D. O'Halloran; S.R. Bloom
- Book ID
- 118398513
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 66 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0167-0115
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Endothelin-1 is mainly synthesized by the vascular endothelial cells and acts on the vascular smooth muscle. Because of its vasoconstrictor and mitogenic effects it plays a role in the development of vascular diseases. In diabetes mellitus atherosclerosis is accelerated. The authors summarize the av