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Elevated factor VIII enhances thrombin generation in the presence of factor VIII-deficiency, factor XI-deficiency or fondaparinux

✍ Scribed by Fania Szlam; Gautam Sreeram; Cristina Solomon; Jerrold H. Levy; Ross J. Molinaro; Kenichi A. Tanaka

Book ID: 116914579
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 580 KB
Volume: 127
Category: Article
ISSN: 0049-3848
DOI: 10.1016/j.thromres.2010.10.017

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## Abstract ## Background Gene therapy for hemophilia A with adeno‐associated virus (AAV) vectors involves difficulties in the efficient expression of factor VIII (FVIII) and in antibody formation against transgene‐derived FVIII. ## Methods AAV8 vectors carrying the canine B domain deleted FVIII