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Electrophoretic studies of antimitochondrial antibodies: Identification of mitochondrial antigens specific to primary biliary cirrhosis

โœ Scribed by Hideo Ishii; Daisaku Muno; Professor Toshihiko Namihisa


Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
681 KB
Volume
10
Category
Article
ISSN
0173-0835

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Antimitochondrial antibodies are characteristically detected in sera of patients with primary biliary cirrhosis. The antigens to which the antimitochondrial antibodies in primary biliary cirrhosis sera react have been located in the mitochondrial inner membrane. We have reported on four mitochondria

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Antimitochondrial antibodies from patients with primary biliary cirrhosis react with different mitochondrial polypeptides as demonstrated by Western blots. The IgG fractions of a patient with primary biliary cirrhosis Stage I reacting exclusively with a pair of polypeptides a t 48,000 daltons (p 48)