First aromatic electrophilic iodination
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Gemma Arsequell; Gemma EspuΓ±a; Gregorio Valencia; JosΓ© Barluenga; Raquel PΓ©rez C
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Article
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1998
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Elsevier Science
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French
β 251 KB
Direct iodination of Tyr residues of peptides anchored on solid supports was accomplished, for the first time, by aromatic eleclrophilic attack of iodonium ions provided by the IPy2BF 4 reagent. Compatibility studies of the iodination with routine solid-phase synthesis protocols are reported.