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Electronic and steric control in carbon-hydrogen insertion reactions of diazoacetoacetates catalyzed by dirhodium(II) carboxylates and carboxamides

✍ Scribed by Doyle, Michael P.; Westrum, Larry J.; Wolthuis, Wendelmoed N. E.; See, Marjorie M.; Boone, William P.; Bagheri, Vahid; Pearson, Matthew M.


Book ID
115545099
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
959 KB
Volume
115
Category
Article
ISSN
0002-7863

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Conformational and electronic preference
✍ Michael P. Doyle; Jack Taunton; Hoan Q. Pho πŸ“‚ Article πŸ“… 1989 πŸ› Elsevier Science 🌐 French βš– 256 KB

Conformational preferences dominate electronic influences in governing regioselectivity for catalytic C-H insertion reactions of diazoacetoacetamides and allow the construction of fl-lactams by insertion a and f3 to an ester functional group. We have recently reported a new methodology for the synt