Electron topology investigation of the structure-activity relationship in the series of α-chymotrypsin inhibitors
✍ Scribed by A. S. Dimoglo; M. Yu. Gorbachev; Yu. M. Chumakov; I. B. Bersuker; L. S. Gitlina; V. E. Golender; A. B. Rozenblum
- Book ID
- 112405854
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 440 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0091-150X
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Structure ± acetylcholinesterase (AChE) inhibitor activity'' relationship studies have been performed for three series of N-benzylpiperidine derivatives using the Electronic-Topological Method (ETM) which is a structural approach designed for the investigation of structureproperty relationships. Bio
## Abstract Enzymes are attractive catalysts for the production of optically active compounds in organic solvents. However, their often low catalytic activity in such applications hampers their practical use. To overcome this, we investigated the effectiveness of the covalent modification of α‐chym