Electron impact ionization and fast atom bombardment mass spectrometry of some 3,3-dimethyl-1-(isoxazol-3-yl)triazenes, a new class of potential anticancer agents

✍ Scribed by Laura Orsatti; Roberta Seraglia; Pietro Traldi; Giuseppe Diamantini; Giorgio Tarzia; Andrea Tontini

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 423 KB
• Volume: 30
• Category: Article
• ISSN: 1076-5174
• DOI: 10.1002/jms.1190301108

✦ Synopsis

Abstract

A series of 3,3‐dimethyl‐1‐(isoxazol‐3‐yl)triazenes, potential anticancer agents, were studied by electron impact (EI) ionization and fast atom bombardment mass spectrometry. Their behaviour was compared with that of dacarbazine, 5‐(3,3‐dimethyl‐1‐triazenyl)‐(1__H__)‐imidazole‐4‐carboxamide, which is employed in the treatment of several neoplastic conditions. An interesting EI‐generated decomposition pathway was observed, consisting in the primary formation of [NH~2~CH~3~]^+^ cations, involved in the metabolic pathway of triazenes, as the alkylating agent responsible for the anticancer properties of the drug. A higher thermodynamic stability of the examined compounds than decarbazine was observed, which reasonably reflects the higher chemical stability.