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Electron-capture glc assay of dichlorphenamide

โœ Scribed by C. Schmitt; W. J. A. Vandenheuvel; R. W. Walker; B. Plazonnet

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
313 KB
Volume
68
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

GLC with electron-caputre detection was applied to the assay of the carbonic anhydrase inhibitor dichlorphenamide and demonstrated a sensitivity of 10 ng in 0.5 ml of rabbit serum or whole aqueous humor (congruent to 0.25 ml) from one rabbit eye. After extraction of the drug and internal standard (monochlorphenamide) from the biological fluid, these compounds were converted to their tetramethyl derivatives by a nucleophilic alkylation method. Dichlorphenamide contents of aqueous humor and serum of rabbits treated with this drug are reported.

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