✦ LIBER ✦
Modified electron-capture GLC assay for salsolinol in brain tissue
✍ Scribed by Patrick J. O'Neill; Half G. Rahwan
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 365 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
A modified assay for a neuroamine-derived tetrahydroisoquinoline, salsolinol, is presented. It combines the ease and rapidity of solvent extraction from brain tiessue with the sensitivity of electron-capture GLC. Detection of salsolinol (1,2,3,4-tetrahydro-1-methyl-6,7-isoquinolinediol), the alkaloid derived from condensation of dopamine and acetaldehyde, at levels of 5-10 ng/g of brain tissue is possible. The advantages afforded by the modifications are discussed in relation to existing procedures.