## Abstract The embryonic chick skeletal muscle cells differentiated in cell culture from trypsinβdissociated myoblasts produce a spike response which is tetrodotoxinβsensitive. It has been found that many cells also produce a plateau response which is resistant to tetrodotoxin. The plateau respons
Electrogenesis of embryonic chick skeletal muscle cells differentiated in vitro
β Scribed by Masaakira Kano; Yutaka Shimada; Koichi Ishikawa
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- English
- Weight
- 267 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0021-9541
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β¦ Synopsis
Electrogenesis of embryonic chick skeletal muscle cells differentiated in monolayer cultures was investigated. Muscle fibers in uitro generate spike potentials similar to those of fibers in wino. However, other responses, plateaux resembling those i n heart muscle, are also elicited. These results suggest that a functional differentiation exists i n cultured muscle fibers.
π SIMILAR VOLUMES
## Abstract The development of spike potential mechanisms during cell differentiation was studied in chick myotubes formed in vitro from trypsinβdissociated myoblasts. The spike potential and its rate of rise were measured in myotubes from 4β14 day old cultures. A depolarizing current pulse was del