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Electrochemical study of the oxidation of carbidopa and its determination using liquid chromatography with electrochemical detection

✍ Scribed by P. Tömpe; A.N. Halbauer; L. Ladanyi

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
567 KB
Volume
273
Category
Article
ISSN
0003-2670

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✦ Synopsis

The electrochenucal oxldatlon of carbldopa [(SM -)_2_(3,4-dlhydroxybenzyl>2-hydrazmoproplomc actd monohydrate] was studled by hnear sweep voltammetry, cychc vokunmetry, nucrucoulometry and preparative electrolysis An ECCE mechamsm wrth two-electron transfer, followed by two chemical reactlons (decarboxylation and hydrolysis), were found, gwmg car&on dloxlde, hydrazrne and 3,4_dlhydroxyphenylacetone The final electrochenucal step may be a reversible two-electron oxldatlon process which uves the o-qumoldal analogue of the latter An analogous ondatlon mechanism was found when carbldopa was ondlzed with HBrCI, m hydrochlonc acid

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