𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Electrochemical determination of carboplatin in serum using a DNA-modified glassy carbon electrode

✍ Scribed by Ana Maria Oliveira Brett; Sílvia H. P. Serrano; Tice A. Macedo; Dulce Raimundo; M. Helena Marques; Mauro A. La-Scalea

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
415 KB
Volume
8
Category
Article
ISSN
1040-0397

No coin nor oath required. For personal study only.

✦ Synopsis

An electrochemical method for the determination of the anticancer platinum drug carboplatin using a DNA-modified electrode was developed. This electrode was successfully used for the electrochemical determination of carboplatin in serum samples of patients with ovarian cancer undergoing treatment. The electrochemical results clearly demonstrated that, for low concentrations, carboplatin interacts preferentially with adenine rather than guanine groups in the DNA and they can contribute to clarifying the mechanisms of interaction of platinum anticancer drugs with DNA. The pharmacokinetics c o r m ondIng to the administration of the drug was followed electrochemically and the detection limit in serum samples was 5.7 x 10 M. Due to a similar mechanism of reaction with DNA other platinum anticancer drugs can be determined by this method.

📜 SIMILAR VOLUMES

Electrochemical Redox Behavior of Omepra
Electrochemical Redox Behavior of Omeprazole Using a Glassy Carbon Electrode
✍ S. M. A. Jorge; A. D. R. Pontinha; A. M. Oliveira-Brett 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 322 KB

## Abstract The electrochemical redox behavior of omeprazole (OMZ), a gastric acid pump inhibitor, was investigated at a glassy carbon electrode using cyclic, differential pulse and square‐wave voltammetry over a wide pH range. The pH‐dependent oxidation occurs in two irreversible consecutive charg

Adsorptive Stripping Voltammetric Detect
Adsorptive Stripping Voltammetric Detection of Single-Stranded DNA at Electrochemically Modified Glassy Carbon Electrode
✍ Huai-Sheng Wang; Huang-Xian Ju; Hong-Yuan Chen 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 292 KB 👁 2 views

## Abstract Electrochemically modified glassy carbon electrode (GCE) was used to study the electrochemical oxidation and detection of denatured single‐stranded (ss) DNA by means of adsorptive stripping voltammetry. The modification of GCE, by electrochemical oxidation at +1.75 V (vs.SCE) for 10 min

Determination of Theophylline at a Cyste
Determination of Theophylline at a Cysteic Acid Modified Glassy Carbon Electrode
✍ Barbara Brunetti; Elio Desimoni 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 206 KB 👁 2 views

## Abstract A glassy carbon electrode modified with electrodeposited cysteic acid is proposed for the determination of theophylline. Estimation of the linear range, calibration function and limit of detection, as well as determination in real samples such as medication tablets were performed.