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Electrochemical Redox Behavior of Omeprazole Using a Glassy Carbon Electrode

✍ Scribed by S. M. A. Jorge; A. D. R. Pontinha; A. M. Oliveira-Brett

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
322 KB
Volume
22
Category
Article
ISSN
1040-0397

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✦ Synopsis

Abstract

The electrochemical redox behavior of omeprazole (OMZ), a gastric acid pump inhibitor, was investigated at a glassy carbon electrode using cyclic, differential pulse and square‐wave voltammetry over a wide pH range. The pH‐dependent oxidation occurs in two irreversible consecutive charge transfer reactions. Adsorption of the nonelectroactive product was also observed. The first oxidation involves removal of one electron, followed by deprotonation and leads to the formation of a hydroxylated species. The second oxidation process is related to the hydroxyl and amino groups in the benzimidazole moiety. The reduction is irreversible, also pH‐dependent, and occurs in a single step at the sulfoxide group in a diffusion‐controlled mechanism. The diffusion coefficient of omeprazole was calculated to be D~OMZ~=2.31×10^−6^ cm^2^ s^−1^.

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