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Electrochemical and spectrophotometric characterisation of protein kinase inhibitor and anticancer drug danusertib

✍ Scribed by Popa, Oana M.; Diculescu, Victor C.

Book ID
121230372
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
761 KB
Volume
112
Category
Article
ISSN
0013-4686

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Protein kinases are now the second largest group of drug targets, and most protein kinase inhibitors in clinical development are directed towards the ATP-binding site. However, these inhibitors must compete with high intracellular ATP concentrations and they must discriminate between the ATP-binding