Protein and lipid kinase inhibitors as targeted anticancer agents of the Ras/Raf/MEK and PI3K/PKB pathways

Discovery of 3-(2-aminoethyl)-5-(3-pheny

Discovery of 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4-dione as a dual inhibitor of the Raf/MEK/ERK and the PI3K/Akt signaling pathways

✍ Qianbin Li; Jingde Wu; Hui Zheng; Kai Liu; Tai L. Guo; Yuying Liu; Scott T. Eble 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 710 KB

A thiazolidine-2,4-dione derivative, 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4-dione (2), was identified as a dual inhibitor of the Raf/MEK/ extracellular signal-regulated kinase (ERK) and the phosphatidylinositol 3-kinase (PI3K)/Akt signaling cascades. The discovered compound inhib