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ELAVL4, PARK10, and the Celts

✍ Scribed by Kristoffer Haugarvoll; Mathias Toft; Owen A. Ross; Jeremy T. Stone; Michael G. Heckman; Linda R. White; Timothy Lynch; John Mark Gibson; Zbigniew K. Wszolek; Ryan J. Uitti; Jan O. Aasly; Matthew J. Farrer

Book ID
102505794
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
64 KB
Volume
22
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Genetic variability in ELAVL4 located in the PARK10 locus was recently associated with age‐at‐onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. We examined five markers spanning ELAVL4 in Norwegian, United States, and Irish PD case–control samples. No association was found between the examined markers and AAO or PD in Norwegian or US samples. However, ELAVL4 markers (rs967582 and rs3902720) were significantly associated with susceptibility to PD in our Irish series. Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic‐founder effect. Β© 2007 Movement Disorder Society

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Saxons, Vikings, and Celts: The Genetic Roots of Britain and Ireland
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From the best-selling author of _The Seven Daughters of Eve_ , a perfect book for anyone interested in the genetic history of Britain, Ireland, and America.One of the world's leading geneticists, Bryan Sykes has helped thousands find their ancestry in the British Isles. _Saxons, Vikings, and Celts_