Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1(MEN1)region
β Scribed by Pachiappan Manickam; Siradanahalli C. Guru; Larisa V. Debelenko; Sunita K. Agarwal; Shodimu-Emmanuel Olufemi; Jane M. Weisemann; Mark S. Boguski; Judy S. Crabtree; Yingping Wang; Bruce A. Roe; Irina A. Lubensky; Zhengping Zhuang; Mary Beth Kester; A. Lee Burns; Allen M. Spiegel; Stephen J. Marx; Lance A. Liotta; Michael R. Emmert-Buck; Francis S. Collins; S. C. Chandrasekharappa
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 121 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0340-6717
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Multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disease characterized by neoplasia of the parathyroid glands, anterior pituitary and endocrine pancreas, is rarely reported in Asian populations. The MEN1 gene, mapped to chromosome 11q13 but yet to be cloned, has been found to be hom
Multiple endocrine neoplasia type 1 (MEN1) is characterized by neoplasia of the parathyroids, the pancreas, and the pituitary. Tumorigenesis involves unmasking of a recessive mutation at the MEN1 locus, which has been mapped to the centromeric part of chromosomal region 11q. In order to localize the