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A novel mutation E179K of the MEN1 gene predisposes for multiple endocrine neoplasia-type 1 (MEN1)

✍ Scribed by Andreas Weinhaeusel; Heinrich Vierhapper; Robert Schlegl; Theresa Wagner; Daniela Muhr; Christian Scheuba; Bruno Niederle; Oskar A. Haas


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
10 KB
Volume
16
Category
Article
ISSN
1059-7794

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Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by tumors in parathyroids, enteropancreatic endocrine tissues, anterior pituitary, and other tissues. The gene for MEN1 has recently been cloned and shown to code for a 610-amino acid protein of enigmatic func

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Multiple endocrine neoplasia type 1 (MEN 1) is a familial cancer syndrome characterized by parathyroid hyperplasia, pituitary adenomas, and neuroendocrine tumors of the pancreas and duodenum. In 1997, the MEN1 tumor suppressor gene was identified, and numerous germline mutations have been reported t