## Abstract Prostaglandins (PGs) and leukotrienes (LTs) derived from arachidonic acid (AA) are potent mediators of inflammation and cell proliferation. Dietary intake of eicosapentaenoic acid (EPA) appears beneficial to both inflammatory processes and cell proliferation. However, there is no clear
Eicosapentaenoic acid and docosahexaenoic acid effects on tumour mitochondrial metabolism, acyl CoA metabolism and cell proliferation
โ Scribed by Alison Colquhoun; Karina L. Ramos; Robert I. Schumacher
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 593 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0263-6484
- DOI
- 10.1002/cbf.902
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The effect of individual administration of low doses of highly purified eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (1 g/kg body weight) on the growth of Morris hepatocarcinoma 3924A transplanted in ACI/T rats was investigated. Both EPA and DHA inhibited growth of the hepatocarcinoma
Fatty acids, particularly the v-3 and v-6 essential fatty acids (EFAs), are considered critical nutritional sources for the developing fetus. The placenta governs the fetal supply of fatty acids via two processes: transport and metabolism. Placental fatty acid metabolism can play a critical role in
## Abstract The mRNA expression levels of acylโCoA oxidase (AOX), a key enzyme in veryโlongโchain fatty acid peroxisomal oxidation, and of peroxisome proliferatorโactivated receptorโฮด (PPARโฮด), a nuclear receptor possibly involved in the gene regulation of brain lipid metabolism, were determined in