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EGFR protein overexpression and mutation in areca quid–associated oral cavity squamous cell carcinoma in Taiwan

✍ Scribed by Shiang-Fu Huang; Wen-Yu Chuang; I-How Chen; Chun-Ta Liao; Hung-Ming Wang; Ling-Ling Hsieh

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
349 KB
Volume
31
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background.

Epidermal growth factor receptor (EGFR)‐targeted therapy has been extensively assessed in human cancer treatment. We appraised the possible role of tyrosine kinase inhibitors (TKIs) in areca quid (AQ)‐associated oral cavity squamous cell carcinomas (OSCCs) by examining EGFR protein overexpression and its tyrosine kinase domain mutations.

Methods.

EGFR overexpression was evaluated by immunohistochemical staining, and tyrosine kinase mutations was determined by direct sequencing of DNAs from 172 OSCC tumors.

Results.

Overexpression of EGFR was found in 27.9% (48 of 172) of the OSCCs and was associated with lymph node metastasis (p = .013) and extracapsular spread (p = .022). Only 1 (0.58%) OSCC displayed somatic EGFR mutation but in a silent form (T725T, ACG→ACA).

Conclusion.

EGFR‐targeted therapy might have some potential in AQ‐associated OSCCs for their EGFR frequently overexpressed, although EGFR mutations were rare. However, the feasibility of TKIs in AQ‐associated OSCCs needs further clinical testing. © 2009 Wiley Periodicals, Inc. Head Neck, 2009

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In Table I of the above-noted article, the column head ''Betel-liquid'' should have been ''betel-quid''. The corrected Table is reprinted here.