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EGFR mutation analysis in sputum of lung cancer patients: A multitechnique study

✍ Scribed by Hubers, A. Jasmijn; Heideman, Daniëlle A.M.; Yatabe, Yasushi; Wood, Michelle D.; Tull, Justyna; Tarón, Miquel; Molina, Miquel A.; Mayo, Clara; Bertran-Alamillo, Jordi; Herder, Gerarda J.M.; Koning, Remco; Sie, Daoud; Ylstra, Bauke; Meijer, Gerrit A.; Snijders, Peter J.F.; Witte, Birgit I.; Postmus, Pieter E.; Smit, Egbert F.; Thunnissen, Erik


Book ID
123413211
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
651 KB
Volume
82
Category
Article
ISSN
0169-5002

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K-ras mutation appears in about 60% of patients with non-small-cell lung cancer (NSCLC). This freqLency and its presence in normal appearing tissues point to the potential of ras oncogene mutation to serve as a good biomarker. Using enriched PCR (EPCR), which enables the detection of one mutant alle