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EGFR-dependent ERK activation triggers hydrogen peroxide-induced apoptosis in OK renal epithelial cells

✍ Scribed by Ju Suk Lee; Su Yung Kim; Chae Hwa Kwon; Yong Keun Kim


Book ID
105870375
Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
512 KB
Volume
80
Category
Article
ISSN
0340-5761

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Cisplatin induces apoptosis in a variety of cell types. However, the signaling pathway of cisplatin-induced apoptosis in renal epithelial cells is poorly understood. The present study was undertaken to determine the role of the extracellular signal-regulated kinase (ERK) in cisplatin-induced apoptos