EGF stimulates the processing and export of a secreted form of EGF receptor
โ Scribed by Jayant Khire; Manjusri Das
- Book ID
- 115923271
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 406 KB
- Volume
- 272
- Category
- Article
- ISSN
- 0014-5793
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NA and Ca9-22 cells derived from squamous cell carcinomas of the tongue possess a large number of epidermal growth factor (EGF) receptors (2.0 x 10" and 1.3 x l o 6 receptorsicell, respectively). In these cell lines, EGF stimulated receptor autophosphorylation and phosphatidylinositol (PI) turnover.
## Abstract Heparinโbinding EGFโlike growth factor (HBโEGF), which belongs to the EGFโfamily of growth factors, was isolated from the conditioned medium of macrophageโlike cells. To investigate the effect of __N__โ and __C__โterminal residues of the EGFโlike domain of HBโEGF in the binding affinity