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EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells

✍ Scribed by Masahito Shimizu; Atsuko Deguchi; Yukihiko Hara; Hisataka Moriwaki; I. Bernard Weinstein

Book ID
116290937
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
412 KB
Volume
334
Category
Article
ISSN
0006-291X

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## Abstract ## BACKGROUND High concentrations of insulin‐like growth factor (IGF)‐I and IGF‐II have been demonstrated in human colonic adenocarcinomas and exert mitogenic effects through paracrine/autocrine interactions with the IGF‐I receptor (IGF‐IR). However, definitive studies of IGF‐IR expres