Efficient two-step sequence for the synthesis of 2,5-disubstituted furan derivatives from functionalized nitroalkanes: successive Amberlyst A21- and Amberlyst 15-catalyzed processes

ChemInform Abstract: Efficient Two-Step

ChemInform Abstract: Efficient Two-Step Sequence for the Synthesis of 2,5-Disubstituted Furan Derivatives from Functionalized Nitroalkanes: Successive Amberlyst A21- and Amberlyst 15-Catalyzed Processes.

✍ Alessandro Palmieri; Serena Gabrielli; Roberto Ballini 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 41 KB 👁 1 views

## Abstract The reaction of ketal‐functionalized nitroalkanes with α‐oxoaldehydes, promoted by Amberlyst A21 and followed by acidic treatment of the mixture with Amberlyst 15, avoids isolation of the nitroaldol intermediates and leads directly to formation of the desired furan derivatives.