Efficient total synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autacoid

✍ Scribed by Suchismita Mohapatra; Jorge H Capdevila; Robert C Murphy; John M Hevko; J.R Falck

• Book ID: 104230734
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 65 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)00668-2

✦ Synopsis

The title eicosanoid was prepared in good overall yield via a convergent aldol strategy that obviates the need for HPLC separation of olefinic isomers.