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Efficient Tandem Biocatalytic Process for the Kinetic Resolution of Aromatic β-Amino Acids

✍ Scribed by Bian Wu; Wiktor Szymański; Stefaan de Wildeman; Gerrit J. Poelarends; Ben L. Feringa; Dick B. Janssen

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 230 KB
Volume: 352
Category: Article
ISSN: 1615-4150
DOI: 10.1002/adsc.201000035

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✦ Synopsis

Abstract

We describe a simple and efficient enzymatic tandem reaction for the preparation of enantiomerically pure β‐phenylalanine and its analogues from the corresponding racemates. In this process, phenylalanine aminomutase (PAM) catalyzes the stereoselective isomerization of (R)‐β‐phenylalanines to (S)‐α‐phenylalanines, which are in situ transformed to cinnamic acids by phenylalanine ammonia lyase (PAL). Preparative scale conversions are done with a mutated PAM with enhanced catalytic activity.

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