Efficient Synthesis of γ-Lactones via Gold-Catalyzed Tandem Cycloisomerization/Oxidation
✍ Scribed by Shu, Chao; Liu, Meng-Qi; Sun, Yu-Zhe; Ye, Long-Wu
- Book ID
- 120477277
- Publisher
- American Chemical Society
- Year
- 2012
- Tongue
- English
- Weight
- 322 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1523-7060
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📜 SIMILAR VOLUMES
The formation of 4-alkoxy-2(5H)-furan-A C H T U N G T R E N N U N G ones was achieved via tandem alkoxylation/lactonization of g-hydroxy-a,b-acetylenic esters catalyzed by 2 mol% of [2,6-bis(diisopropylphenyl)imidazol-2-ylidine]gold bis(trifluoromethanesulfonyl)imidate
## Abstract Both enantiomers of the six major kinds of __γ__‐lactones were synthesized to >98% e.e. in four steps, starting from succinic anhydride. The key features were the syntheses of the various __rac__‐__N__‐methyl‐4‐hydroxyalkanamides via Grignard reaction and the enantioselective acetylatio