✦ LIBER ✦

Efficient Synthesis of α,β-Epoxy Carbonyl Compounds in Acetonitrile: Darzens Condensation of Aromatic Aldehydes with Ethyl Chloroacetate

✍ Scribed by Zong-Ting Wang; Li-Wen Xu; Chun-Gu Xia; Han-Qing Wang

Publisher: John Wiley and Sons
Year: 2004
Tongue: German
Weight: 86 KB
Volume: 87
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200490177

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The Darzens reaction of ethyl 2‐chloroacetate (1) with aromatic aldehydes 2 in the presence of polymer‐supported or nonsupported quaternary ammonium salts proceeds under mild conditions by phase‐transfer catalysis to give the corresponding epoxides 3 in satisfactory yields (Tables 1 and 2). With both MeCN as solvent and polystyrene‐supported catalysts, diastereoselective Darzens reactions proceed in excellent yields and short times, with a fair degree of stereoinduction.

📜 SIMILAR VOLUMES

Efficient Synthesis of α,β-Epoxy Carbony

Efficient Synthesis of α,β-Epoxy Carbonyl Compounds in Acetonitrile: Darzens Condensation of Aromatic Aldehydes with Ethyl Chloroacetate.

✍ Zong-Ting Wang; Li-Wen Xu; Chun-Gu Xia; Han-Qing Wang 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 25 KB

Novel and Efficient One Pot Condensation

Novel and Efficient One Pot Condensation Reactions between Ketones and Aromatic Alcohols in the Presence of CrO3 Producing α,β-Unsaturated Carbonyl Compounds

✍ Yanan Li; Daoyong Chen 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 87 KB 👁 1 views

ChemInform Abstract: Novel and Efficient

ChemInform Abstract: Novel and Efficient One Pot Condensation Reactions Between Ketones and Aromatic Alcohols in the Presence of CrO3 Producing α,β-Unsaturated Carbonyl Compounds.

✍ Yanan Li; Daoyong Chen 📂 Article 📅 2012 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views