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Efficient Synthesis of α,β-Epoxy Carbonyl Compounds in Acetonitrile: Darzens Condensation of Aromatic Aldehydes with Ethyl Chloroacetate.

✍ Scribed by Zong-Ting Wang; Li-Wen Xu; Chun-Gu Xia; Han-Qing Wang


Publisher
John Wiley and Sons
Year
2004
Weight
25 KB
Volume
35
Category
Article
ISSN
0931-7597

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Efficient Synthesis of α,β-Epoxy Carbony
✍ Zong-Ting Wang; Li-Wen Xu; Chun-Gu Xia; Han-Qing Wang 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 German ⚖ 86 KB

## Abstract The __Darzens__ reaction of ethyl 2‐chloroacetate (**1**) with aromatic aldehydes **2** in the presence of polymer‐supported or nonsupported quaternary ammonium salts proceeds under mild conditions by phase‐transfer catalysis to give the corresponding epoxides **3** in satisfactory yiel