a-Amino g-lactones were generated by an InCl 3 -mediated or Sc(OTf) 3 -catalyzed three-component reaction of alkenes, glyoxylates and amines.
Efficient Synthesis of α-Quaternary α-Hydroxy-β-amino Esters via Silyl Glyoxylate-Mediated Three-Component Reactions
✍ Scribed by Jiang, Jiu-Long; Yao, Ming; Lu, Chong-Dao
- Book ID
- 126121449
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 446 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1523-7060
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## Abstract An easily available and efficient chiral __N__,__N__′‐dioxide–nickel(II) complex catalyst has been developed for the direct catalytic asymmetric aldol reaction of α‐isothiocyanato imide with aldehydes which produces the products in morderate to high yields (up to 98 %) with excellent di