A simple and highly efficient synthesis of β-amino-α, β-unsaturated ester via sonochemical Blaise reaction
✍ Scribed by Adam Shih-Yuan Lee; Rae-Yi Cheng; Ohm-Guo Pan
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 199 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
lS-Amino-ot,13-unsaturated ester is produced by a sonochemical Blaise reaction of nitrile, zinc powder, zinc oxide and ethyl bromoacetate in THF in a commercial ultrasonic cleaning bath.
📜 SIMILAR VOLUMES
Under a proper reaction condition, simple ester enolates add to d,e-unsaturated esters highly stereoselectively to give erythro or threoglutarates. Previously, we have shown that lithium enolates derived from simple monoesters react with fi,p-unsaturated esters to give glutarates in high yiela. 1)
D-Mono-and p,P-disubstituted a,P-unsaturated esters can be prepared in good yields stereoselectively by the stepwise alkylation and alkoxycarbonylation of 2-bromo-l-alkenylboronates. Recently, we have demonstrated that the stepwise cross-coupling reactions of 2-bromo-lalkenylboranes, readily obtain