Synthetic approach towards nakadomarin A
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Toshiaki Nagata; Atsushi Nishida; Masako Nakagawa
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Article
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2001
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Elsevier Science
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French
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An efficient synthesis of the tetracyclic core of nakadomarin A was accomplished starting from methyl 4-oxo-3-piperidinecarboxylate. The key steps were intramolecular cyclization of furan to N-acyliminium ions to construct the strained central cyclopentene ring.