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Efficient synthesis of the gadolinium complex of a new C2-symmetric tetramine

✍ Scribed by Michael Harre; Klaus Nickisch; Claudia Schulz; Hilmar Weinmann

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
203 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A short and efficient synthesis of the substituted tetramines 2a and 7 and of the gadolinium complex 1 was developed starting from the Cbz-protected amino alcohol 3. Key steps of the synthesis are the optimized bleach oxidation of enantiopure alcohols and the bridging of the resulting aldehyde molecules by double reductive amination with ethylenediamine. Interesting biological activity of the amines 2a and 7 was detected.

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