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Efficient Synthesis of Pyrroles from Chemoselective Addition of Primary Amines to 1,6-Dioxo-2,4-dienes

✍ Scribed by Ong, Chi Wi; Chen, Chong Meng; Wang, Long Hu; Jan, Jiing Jyh; Shieh, Po Chuen

Book ID: 127155488
Publisher: American Chemical Society
Year: 1998
Tongue: English
Weight: 48 KB
Volume: 63
Category: Article
ISSN: 0022-3263
DOI: 10.1021/jo981566x

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## Abstract A one‐pot synthesis of dialkyl 1,3a,4,8b‐tetrahydro‐3a,8b‐dihydroxy‐1‐alkyl‐4‐oxoindeno[1,2‐__b__]pyrrole‐2,3‐dicarboxylates __via__ three‐component reaction from indan‐1,2,3‐trione hydrate (ninhydrin), primary amines, and dialkyl acetylenedicarboxylates is described.

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