Efficient Synthesis of Ningalin C.
β Scribed by Anucha Namsa-aid; Somsak Ruchirawat
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 24 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0931-7597
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract A synthesis of the title compound from ^13^CO~2~ is described. The final step utilizes lithium hexamethyldisilazide as a base in the double dehydrobromination of 1,2βdibromoethaneβ1β^13^C. Some alternative procedures are discussed.
Various routes to fbnctionalized benzenes labelled in position 1 were compared. 1-[ 13Cl-Bromobenzene has been synthesized in 7 steps with an overall yield of 5.4% from [ I 3C]-BaC03, by optimizing the direct transformation of p-nitrophenol into bromobenzene.