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Efficient Synthesis of New Thieno[2,3- d ]pyrimidin-4(3 H )-one Derivatives for Evaluation as Anticancer Agents

✍ Scribed by Hu, Yang-Gen; Zheng, Ai-Hua; Li, Gao-Jun; Dong, Meng-Zhu; Ye, Fang; Sun, Feng; Liu, Zheng-Yun; Li, Wen


Book ID
121801002
Publisher
Journal of Heterocyclic Chemistry
Year
2014
Tongue
English
Weight
561 KB
Volume
51
Category
Article
ISSN
0022-152X

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## Abstract magnified image The carbodiimides **5**, obtained from reactions of iminophosphorane **4** with aromatic isocyanates, reacted with amines, phenols or ROH to give 2‐substituted 5,6,7,8‐tetrahydropyrido[4′,3′:4,5]thieno[2,3‐__d__]‐pyrimidin‐4(3__H__)‐one 7 in the presence of catalytic am

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## Abstract A series of new 2‐substituted 3‐(4‐chlorophenyl)‐5,8,9‐trimethylthieno[3′,2′: 5,6]pyrido[4,3‐__d__]pyrimidin‐4(3__H__)‐ones **8** were synthesized __via__ an aza‐__Wittig__ reaction. Phosphoranylideneamino derivatives **6a** or **6b** reacted with 4‐chlorophenyl isocyanate to give carbo