Efficient synthesis of N1- or N3-substituted thieno[2,3-d]imidazol-2-ones
✍ Scribed by Frédéric Fabis; Sandrine Jolivet-Fouchet; Sylvain Rault
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 367 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
## Abstract The carbodiimides **4**, obtained from reactions of iminophosphorane **3** with aromatic isocyanates, were reacted with secondary amines to give 2‐dialkylamino‐5‐ethyl‐6‐methyl‐thieno[2,3‐__d__]pyrimidin‐4(3__H__)‐ones **6** in the presence of catalytic amount of EtONa. Reactions of **4
## Abstract The reaction of ethyl 2‐isothiocyanato‐3‐thiophenecarboxylates 1 with anions of acyclic as well as of cyclic 1,3‐diketones or diethyl malonate affords diacylthioacetamide derivatives 2. Upon treatment with concd. sulfuric acid 2a‐1 are transformed into novel 2‐substituted thieno[2.,3‐__
## Abstract magnified image The interaction of both 2‐iminocoumarin‐3‐carbonitriles and 2‐iminocoumarin‐3‐carbothioamides with 2‐aminothiophen‐3‐carboxamides lead to formation of 3‐(4‐oxo‐3,4‐dihydrothieno[2,3‐__d__]pyrimidin‐2‐yl)‐2‐iminocoumarins in two steps. The simplicity of the procedure, as