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Efficient Synthesis of Losartan, A Nonpeptide Angiotensin II Receptor Antagonist

โœ Scribed by Larsen, Robert D.; King, Anthony O.; Chen, Cheng Y.; Corley, Edward G.; Foster, Bruce S.; Roberts, F. Edward; Yang, Chunhua; Lieberman, David R.; Reamer, Robert A.


Book ID
115479478
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
520 KB
Volume
59
Category
Article
ISSN
0022-3263

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Facile synthesis of novel nonpeptide ang
โœ Ling-Chun Yang; Guan-Xin Zhang; Nan-Zhi Zou; Chuan-Min Qi ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 65 KB

## Abstract A series of Losartan analogues **1โ€12** with different functional groups were synthesized and characterized. In comparison with the previous reports, the synthetic procedures described in this paper have been optimized as follows below: 1) preparation of aromatic amine **15** and **18**