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Efficient synthesis of imidazopyridodiazepines from peri annulation in imidazo[1,2-a]pyridine

✍ Scribed by C. Dechambre; Jean M. Chezal; E. Moreau; F. Estour; B. Combourieu; G. Grassy; A. Gueiffier; C. Enguehard; V. Gaumet; Olivier Chavignon; Jean C. Teulade


Book ID
104252396
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
304 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis


In 3-amino imidazopyridines, complete C(5) regiospecificity yielded corresponding TIBO-like derivatives (Β±)-3a, 6a and (Β±)-8a-c. The structures of these polycyclic compounds containing the azaindole moiety were determined by 1D and 2D NMR, and by X-ray crystallography.


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ethoxycarbonylmethylene)-2,3,4,5-tetrahydroimidazole undergoes annulation with a variety of 1,3-bis-eleetrophiles (a,ll-unsaturated acid derivatives, 13-ketoesters, a, lt-unsaturated aldehydes) to form imidazo[l,2-a]pyridines.

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