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Efficient synthesis of highly enantiopure β-lactam derivatives from biocatalytic transformations of amides and nitriles

✍ Scribed by Ao, Yu-Fei; Leng, Dong-Hui; Wang, De-Xian; Zhao, Liang; Wang, Mei-Xiang

Book ID
122300954
Publisher
Elsevier Science
Year
2014
Tongue
French
Weight
667 KB
Volume
70
Category
Article
ISSN
0040-4020

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Under very mild conditions, the Rhodococcus sp. AJ270-catalysed biotransformation of arylglycine nitriles 1, prepared easily from the reaction of substituted benzaldehydes, ammonium chloride and potassium cyanide, proceeded efficiently to produce optically active D-arylglycine amides 2 and L-arylgly