Highly efficient and enantioselective synthesis of l-arylglycines and d-arylglycine amides from biotransformations of nitriles

✍ Scribed by Mei-Xiang Wang; Shuang-Jun Lin

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 130 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01439-3

✦ Synopsis

Under very mild conditions, the Rhodococcus sp. AJ270-catalysed biotransformation of arylglycine nitriles 1, prepared easily from the reaction of substituted benzaldehydes, ammonium chloride and potassium cyanide, proceeded efficiently to produce optically active D-arylglycine amides 2 and L-arylglycines 3 in excellent yields with enantiomeric excesses higher than 99%.