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Efficient Synthesis of Functionalized Thiazoles from Acid Chlorides, Tetramethylthiourea, Ethyl Bromopyruvate, and Ammonium Thiocyanate

✍ Scribed by Issa Yavari; Zinatossadat Hossaini; Samereh Seyfi; Faezeh Shirgahi-Talari

Publisher: John Wiley and Sons
Year: 2008
Tongue: German
Weight: 154 KB
Volume: 91
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200890127

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✦ Synopsis

Abstract

An efficient synthesis of ethyl 2‐(dimethylamino)‐1,3‐thiazole‐4‐carboxylates is described via a four‐component reaction between acid chlorides, tetramethylthiourea, ethyl bromopyruvate, and ammonium thiocyanate.

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