Efficient Synthesis of a GABA A α 2,3 -Selective Allosteric Modulator via a Sequential Pd-Catalyzed Cross-Coupling Approach
✍ Scribed by Jensen, Mark S.; Hoerrner, R. Scott; Li, Wenjie; Nelson, Dorian P.; Javadi, Gary J.; Dormer, Peter G.; Cai, Dongwei; Larsen, Robert D.
- Book ID
- 120416737
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 129 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0022-3263
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Nakienone A was synthesized for the first time from 3-methoxy-2-cyclopentenone, dienyl iodide 7, and LiCI-I2OMOM in 8 steps in 26% overall yield with full control of the alkene geometry using the Pal-catalyzed cross coupling reaction of a cyclopentenylzinc derivative 6a with 7 as a key step.