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Efficient Synthesis of 4-Fluoro-5-(perfluoroalkyl)pyrazoles from Organofluorosilicon Building Blocks

✍ Scribed by Jean-Philippe Bouillon; Benoît Didier; Boniface Dondy; Pascale Doussot; Richard Plantier-Royon; Charles Portella

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 358 KB
Volume: 2001
Category: Article
ISSN: 1434-193X
DOI: 10.1002/1099-0690(200101)2001:1<187::aid-ejoc187>3.0.co;2-g

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✦ Synopsis

A series of 4-fluoro-5-(perfluoroalkyl)pyrazoles has been prepared by heterocyclization of hemiperfluoroenones 3 or synthetic equivalents 1 and 2 with methylhydrazine. Compounds 1-3 were obtained by reaction of acylsilanes and perfluoroorganometallic reagents. The fluorinated pyrazoles could also be prepared in a one-pot reaction from the starting acylsilanes. This method is very general and has been ap-[ ‡] Mixed OrganofluorineϪOrganosilicon Chemistry, 11. Ϫ Part 10: Ref.

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