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Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-one Using Metal Hydrogen Sulfates M(HSO4)n as Catalyst under Solvent-Free Conditions

✍ Scribed by Khodabakhsh NIKNAM; Mohammad Ali ZOLFIGOL; Zahra HOSSIENINEJAD; Nader DANESHVAR


Book ID
108499142
Publisher
Elsevier Science
Year
2007
Weight
366 KB
Volume
28
Category
Article
ISSN
1872-2067

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Synthesis of 3,4-dihydropyrimidin-2(1H)-
✍ Atul Kumar; Ram Awatar Maurya πŸ“‚ Article πŸ“… 2007 πŸ› Elsevier Science 🌐 English βš– 164 KB

A Ziegler-Natta catalyst system (TiCl 4 -MgCl 2 /magnesium chloride-methanol adduct) was efficiently found to catalyze the three component Biginelli reaction of an aldehyde, ␀-keto ester, and urea or thiourea under solvent free conditions to afford the corresponding 3,4-dihydropyrimidin-2-(1H)-ones